Carnitine and congeners as regulators of tumour necrosis factor
نویسندگان
چکیده
منابع مشابه
L-carnitine alleviates alcohol-induced liver damage in rats: role of tumour necrosis factor-alpha.
AIMS Excessive alcohol intake induces hepatic fatty infiltration, which has been suggested to sensitize the liver to further damage. To test this hypothesis, L-carnitine, a constitutional lipotropic compound, was administered to rats chronically treated with ethanol by liquid diet feeding for 10 weeks. RESULTS Ethanol administration caused marked steatosis, mild inflammation and elevated plas...
متن کاملAnaesthetics modulate tumour necrosis factor α: effects of L-carnitine supplementation in surgical patients. Preliminary results.
Both anaesthetics and surgical trauma could strongly affect the production of tumour necrosis factor alpha (TNFalpha). During in vitro experiments the authors found that anaesthetics modulate the production of TNFalpha by peripheral blood mononuclear cells. Notably, Pentothal strongly increased the production of the cytokine as compared to both lipopolysacchride treated and control mononuclear ...
متن کاملSignal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Many biological functions are regulated through interactions of extracellular molecules with their cognate cell surface receptors. The transduction of these signals by their receptors at the plasma membrane to the intracellular machinery results in such cellular activities as gene activation, protein phosphorylation, cell proliferation, and cell destruction. Though the kinetics of these activit...
متن کاملPentoxifylline and tumour necrosis factor-induced
Acute Gram-negative bacterial infections evoke characteristic pathophysiological responses, including changes in white blood cell counts, fever, haemodynamic disorders, and various coagulatory disturbances, which may result in respiratory distress syndrome, multiorgan failure and irreversible shock. It is generally accepted that endotoxins, the lipopolysaccharides (LPS) of Gramnegative bacteria...
متن کاملTumour necrosis factor haplotypes and asthma.
Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC. In this study, 413 subjects in 88 nuclear families from a general population sample were examined for association with asthma and TNF polymorphism...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 1993
ISSN: 0962-9351,1466-1861
DOI: 10.1155/s0962935193000663